Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular senescence: a link between cancer and age-related degenerative disease?

Seminars in cancer biology - 1 Dec 2011

Campisi Judith, Andersen Julie K, Kapahi Pankaj, Melov Simon

Abstract excerpt

Cellular senescence is an established cellular stress response that acts primarily to prevent the proliferation of cells that experience potentially oncogenic stress. In recent years, it has become increasingly apparent that the senescence response is a complex phenotype, which has a variety of cell non-autonomous effects. The senescence-associated secretory phenotype, or SASP, entails the secretion of numerous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Cellular Senescence
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetics, Aging, and Longevity in Model Organisms

Share to Neoplasms

Share to Phenotype

Share to Telomeres, Telomerase, and Senescence

Source

Open in PubMed Open full text

Identifiers

PMID: 21925603
DOI: 10.1016/j.semcancer.2011.09.001
PMCID: PMC3230665

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular senescence: a link between cancer and age-related degenerative disease?PMID 21925603Read ↗

Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype.Semantic proximity Read ↗

Senescent cells and their secretory phenotype as targets for cancer therapy.Semantic proximity Read ↗

The senescence-associated secretory phenotype and its physiological and pathological implications.Semantic proximity Read ↗

From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes.Semantic proximity Read ↗

Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases.Semantic proximity Read ↗

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.Semantic proximity Read ↗

Epigenetic Regulation of Cellular SenescenceSemantic proximity Read ↗

Cellular senescence: putting the paradoxes in perspective.Semantic proximity Read ↗

Senescent cells at the crossroads of aging, disease, and tissue homeostasisSemantic proximity Read ↗

Cellular Senescence: Aging, Cancer, and InjurySemantic proximity Read ↗

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cellsSemantic proximity Read ↗

Cellular senescence: Molecular mechanisms and pathogenicitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.