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Article

Germline CDH1 Variants and Lifetime Cancer Risk.

JAMA - 3 Sept 2024

Ryan Carrie E, Fasaye Grace-Ann, Gallanis Amber F, Gamble Lauren A, McClelland Paul H, Duemler Anna, Samaranayake Sarah G, Blakely Andrew M, Drogan Christine M, Kingham Kerry, Patel Devanshi, Rodgers-Fouche Linda, Siegel Ava, Kupfer Sonia S, Ford James M, Chung Daniel C, Dowty James G, Sampson Joshua, Davis Jeremy L

Abstract excerpt

Importance: Approximately 1% to 3% of gastric cancers and 5% of lobular breast cancers are hereditary. Loss of function CDH1 gene variants are the most common gene variants associated with hereditary diffuse gastric cancer and lobular breast cancer. Previously, the lifetime risk of gastric cancer was estimated to be approximately 25% to 83% and for breast cancer it was estimated to be approximately 39% to 55% in...

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Identifiers

PMID: 38873722
DOI: 10.1001/jama.2024.10852
PMCID: PMC11372503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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