Article
Germline CDH1 Variants and Lifetime Cancer Risk.
JAMA - 3 Sept 2024
Ryan Carrie E, Fasaye Grace-Ann, Gallanis Amber F, Gamble Lauren A, McClelland Paul H, Duemler Anna, Samaranayake Sarah G, Blakely Andrew M, Drogan Christine M, Kingham Kerry, Patel Devanshi, Rodgers-Fouche Linda, Siegel Ava, Kupfer Sonia S, Ford James M, Chung Daniel C, Dowty James G, Sampson Joshua, Davis Jeremy L
Abstract excerpt
Importance: Approximately 1% to 3% of gastric cancers and 5% of lobular breast cancers are hereditary. Loss of function CDH1 gene variants are the most common gene variants associated with hereditary diffuse gastric cancer and lobular breast cancer. Previously, the lifetime risk of gastric cancer...
Topics
- Adult
- Aged
- Female
- Humans
- Male
- Middle Aged
- Antigens, CD
- Breast Neoplasms
- Cadherins
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Retrospective Studies
- Risk Assessment
- Stomach Neoplasms