Thymic B Cells as a New Player in the Type 1 Diabetes Response.

doi:10.3389/fimmu.2021.772017

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Article

Thymic B Cells as a New Player in the Type 1 Diabetes Response.

Frontiers in immunology - 1 Jan 2021

Greaves Richard B, Chen Dawei, Green E Allison

Abstract excerpt

Type 1 diabetes (T1d) results from a sustained autoreactive T and B cell response towards insulin-producing β cells in the islets of Langerhans. The autoreactive nature of the condition has led to many investigations addressing the genetic or cellular changes in primary lymphoid tissues that impairs central tolerance- a key process in the deletion of autoreactive T and B cells during their development. For T...

Topics

Animals
B-Lymphocytes
Computer Simulation
Diabetes Mellitus, Type 1
Humans
Models, Biological
Phenotype
Thymus Gland

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Identifiers

PMID: 34745148
DOI: 10.3389/fimmu.2021.772017
PMCID: PMC8566354

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