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The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology

1 Jul 2011

Abstract excerpt

BACKGROUND: The major human intestinal pathogen Giardia lamblia is a very early branching eukaryote with a minimal genome of broad evolutionary and biological interest. RESULTS: To explore early kinase evolution and regulation of Giardia biology, we cataloged the kinomes of three sequenced strains. Comparison with published kinomes and those of the excavates Trichomonas vaginalis and Leishmania major shows that...

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PMID: 21787419
DOI: 10.1186/gb-2011-12-7-r66

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