Article
KREPA6 functions in RNA editing catalytic complex structural organization and gRNA utilization in Trypanosoma brucei.
Nucleic acids research - 19 Mar 2026
Davidge Brittney, Carnes Jason, Lewis Isaac, Rodshagen Tyler, Tracy Maxwell, McDermott Suzanne M, Stuart Kenneth D
Abstract excerpt
Functional mitochondrial mRNAs in Trypanosoma brucei are generated by the post-transcriptional guide RNA (gRNA) directed insertion and deletion of uridine residues, called RNA editing, that is catalyzed by three closely related multiprotein RNA Editing Catalytic Complexes (RECCs). These RECCs contain a common set of 12 proteins including KREPA6 which is largely comprised of an oligonucleotide binding (OB)-fold...
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