Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence.

Nature microbiology - 1 May 2024

Bradley Catherine C, Wang Chen, Gordon Alasdair J E, Wen Alice X, Luna Pamela N, Cooke Matthew B, Kohrn Brendan F, Kennedy Scott R, Avadhanula Vasanthi, Piedra Pedro A, Lichtarge Olivier, Shaw Chad A, Ronca Shannon E, Herman Christophe

Abstract excerpt

RNA viruses, like SARS-CoV-2, depend on their RNA-dependent RNA polymerases (RdRp) for replication, which is error prone. Monitoring replication errors is crucial for understanding the virus's evolution. Current methods lack the precision to detect rare de novo RNA mutations, particularly in low-input samples such as those from patients. Here we introduce a targeted accurate RNA consensus sequencing method...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Viral

Share to Mutation Rate

Share to RNA, Viral

Share to SARS-CoV-2

Share to Sequence Analysis, RNA

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 38649410
DOI: 10.1038/s41564-024-01655-4
PMCID: PMC11384275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence.PMID 38649410Read ↗

Evidence Supporting That C-to-U RNA Editing Is the Major Force That Drives SARS-CoV-2 Evolution.Semantic proximity Read ↗

SARS-CoV-2 genomic diversity and the implications for qRT-PCR diagnostics and transmission.Semantic proximity Read ↗

ADAR mediated A-to-I RNA editing affects SARS-CoV-2 characteristics and fuels its evolutionSemantic proximity Read ↗

Host-specific asymmetric accumulation of mutation types reveals that the origin of SARS-CoV-2 is consistent with a natural processSemantic proximity Read ↗

Highly recurrent multi-nucleotide mutations in SARS-CoV-2Semantic proximity Read ↗

Virus-specific editing identification approach reveals the landscape of A-to-I editing and its impacts on SARS-CoV-2 characteristics and evolution.Semantic proximity Read ↗

Mutation profile of over 4500 SARS-CoV-2 isolations reveals prevalent cytosine-to-uridine deamination on viral RNAs.Semantic proximity Read ↗

Accurate RNA consensus sequencing for high-fidelity detection of transcriptional mutagenesis-induced epimutations.Semantic proximity Read ↗

SNPs or RNA modifications? Concerns on mutation-based evolutionary studies of SARS-CoV-2.Semantic proximity Read ↗

The continuing discovery on the evidence for RNA editing in SARS-CoV-2.Semantic proximity Read ↗

Characterization of SARS-CoV-2 Mutational Signatures from 1.5+ Million Raw Sequencing Samples.Semantic proximity Read ↗

Mutations of SARS-CoV-2 nsp14 exhibit strong association with increased genome-wide mutation loadSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.