Article

Highly recurrent multi-nucleotide mutations in SARS-CoV-2

2024-12-16

Abstract excerpt

Multi-nucleotide mutations (MNMs) simultaneously replace multiple nu-cleotides. They are a significant contributor to evolution and disease, as well as to misdiagnosis, misannotation and other biases in genome data analysis. MNMs are generally thought to be rare and random events. However, by processing millions of publicly shared genomes, we show that certain MNMs are highly recurrent in SARS-CoV-2: they rep...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0c413b3e-9a88-5d74-bcf3-e09d443f9545
DOI: 10.1101/2024.12.14.628346

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Highly recurrent multi-nucleotide mutations in SARS-CoV-2DOI 10.1101/2024.12.14.628346Read

Highly Recurrent Multinucleotide Mutations in SARS-CoV-2.Semantic proximity Read

Stability of SARS-CoV-2 phylogeniesSemantic proximity Read

Stability of SARS-CoV-2 PhylogeniesSemantic proximity Read

Host-specific asymmetric accumulation of mutation types reveals that the origin of SARS-CoV-2 is consistent with a natural processSemantic proximity Read

SARS-CoV-2 genomic diversity and the implications for qRT-PCR diagnostics and transmission.Semantic proximity Read

The Mutational Landscape of SARS-CoV-2.Semantic proximity Read

Evidence Supporting That C-to-U RNA Editing Is the Major Force That Drives SARS-CoV-2 Evolution.Semantic proximity Read

Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence.Semantic proximity Read

Properties and Mechanisms of Deletions, Insertions, and Substitutions in the Evolutionary History of SARS-CoV-2.Semantic proximity Read

Co-mutation modules capture the evolution and transmission patterns of SARS-CoV-2.Semantic proximity Read

The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structureSemantic proximity Read

Hidden genomic diversity of SARS-CoV-2: implications for qRT-PCR diagnostics and transmissionSemantic proximity Read