Article
SARS-CoV-2 genomic diversity and the implications for qRT-PCR diagnostics and transmission.
Genome research - 1 Apr 2021
Sapoval Nicolae, Mahmoud Medhat, Jochum Michael D, Liu Yunxi, Elworth R A Leo, Wang Qi, Albin Dreycey, Ogilvie Huw A, Lee Michael D, Villapol Sonia, Hernandez Kyle M, Maljkovic Berry Irina, Foox Jonathan, Beheshti Afshin, Ternus Krista, Aagaard Kjersti M, Posada David, Mason Christopher E, Sedlazeck Fritz J, Treangen Todd J
Abstract excerpt
The COVID-19 pandemic has sparked an urgent need to uncover the underlying biology of this devastating disease. Though RNA viruses mutate more rapidly than DNA viruses, there are a relatively small number of single nucleotide polymorphisms (SNPs) that differentiate the main SARS-CoV-2 lineages that have spread throughout the world. In this study, we investigated 129 RNA-seq data sets and 6928 consensus genomes to...
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