Article
SNPs or RNA modifications? Concerns on mutation-based evolutionary studies of SARS-CoV-2.
PloS one - 1 Jan 2020
Li Yue, Yang Xinai, Wang Na, Wang Haiyan, Yin Bin, Yang Xiaoping, Jiang Wenqing
Abstract excerpt
SARS-CoV-2 is still rampaging throughout the world while the many evolutionary studies on it are simultaneously springing up. Researchers have simply utilized the public RNA-seq data to find out the so-called SNPs in the virus genome. The evolutionary analyses were largely based on these mutations. Here, we claim that we reliably detected A-to-G RNA modifications in the RNA-seq data of SARS-CoV-2 with high signal...
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