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Mutation profile of over 4500 SARS-CoV-2 isolations reveals prevalent cytosine-to-uridine deamination on viral RNAs.

Future microbiology - 1 Sept 2020

Li Yue, Yang Xinai, Wang Na, Wang Haiyan, Yin Bin, Yang Xiaoping, Jiang Wenqing

Abstract excerpt

Aim: The inference of coronavirus evolution is largely based on mutations in SARS-CoV-2 genome. Misinterpretation of these mutations would mislead people about the evolution of SARS-CoV-2. Materials & methods: With 4521 lines of SARS-CoV-2, we obtained 3169 unique point mutation sites. We counted the numbers and calculated the minor allele frequency (MAF) of each mutation type. Results: Nearly half of the point...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33085541
DOI: 10.2217/fmb-2020-0149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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