Article

ADAR mediated A-to-I RNA editing affects SARS-CoV-2 characteristics and fuels its evolution

2021-07-22

Abstract excerpt

Upon SARS-CoV-2 infection, viral intermediates activate the Type I interferon (IFN) response through MDA5-mediated sensing and accordingly induce ADAR1 p150 expression, which might lead to A-to-I RNA editing of SARS-CoV-2. Here, we developed an RNA virus-specific editing identification pipeline, surveyed 7622 RNA-seq data from diverse types of samples infected with SARS-CoV-2, and constructed an atlas of A-to-I RN...

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Identifiers and source

Literature Corpus work: 92595659-87a3-542d-9fca-7fb8f4c40795
DOI: 10.1101/2021.07.22.453345

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