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Article

Plk1 Regulates the Repressor Function of FoxM1b by inhibiting its Interaction with the Retinoblastoma Protein.

Scientific reports - 7 Apr 2017

Mukhopadhyay Nishit K, Chand Vaibhav, Pandey Akshay, Kopanja Dragana, Carr Janai R, Chen Yi-Ju, Liao Xiubei, Raychaudhuri Pradip

Abstract excerpt

FoxM1b is a cell cycle-regulated transcription factor, whose over-expression is a marker for poor outcome in cancers. Its transcriptional activation function requires phosphorylation by Cdk1 or Cdk2 that primes FoxM1b for phosphorylation by Plk1, which triggers association with the co-activator CBP. FoxM1b also possesses transcriptional repression function. It represses the mammary differentiation gene GATA3...

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Share to DNA (Cytosine-5-)-Methyltransferases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GATA3 Transcription Factor

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Share to Polo-Like Kinase 1

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Source

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Identifiers

PMID: 28387346
DOI: 10.1038/srep46017
PMCID: PMC5384083

Genes

GATA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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