Article
Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor.
Science (New York, N.Y.) - 3 Aug 2001
Wang H, Huang Z Q, Xia L, Feng Q, Erdjument-Bromage H, Strahl B D, Briggs S D, Allis C D, Wong J, Tempst P, Zhang Y
Abstract excerpt
Acetylation of core histone tails plays a fundamental role in transcription regulation. In addition to acetylation, other posttranslational modifications, such as phosphorylation and methylation, occur in core histone tails. Here, we report the purification, molecular identification, and functional characterization of a histone H4-specific methyltransferase PRMT1, a protein arginine methyltransferase. PRMT1...
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