Article
JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation.
Cancer cell - 15 Feb 2011
Liu Fan, Zhao Xinyang, Perna Fabiana, Wang Lan, Koppikar Priya, Abdel-Wahab Omar, Harr Michael W, Levine Ross L, Xu Hao, Tefferi Ayalew, Deblasio Anthony, Hatlen Megan, Menendez Silvia, Nimer Stephen D
Abstract excerpt
The JAK2V617F constitutively activated tyrosine kinase is found in most patients with myeloproliferative neoplasms. While examining the interaction between JAK2 and PRMT5, an arginine methyltransferase originally identified as JAK-binding protein 1, we found that JAK2V617F (and JAK2K539L) bound PRMT5 more strongly than did wild-type JAK2. These oncogenic kinases also acquired the ability to phosphorylate PRMT5,...
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