Article
Automethylation of protein arginine methyltransferase 7 and its impact on breast cancer progression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2017
Geng Pengyu, Zhang Yu, Liu Xiaoqing, Zhang Na, Liu Yingqi, Liu Xin, Lin Cong, Yan Xu, Li Zhongwei, Wang Guannan, Li Yuxin, Tan Jiang, Liu Dong-Xu, Huang Baiqu, Lu Jun
Abstract excerpt
Protein arginine methyltransferases (PRMTs) catalyze protein arginine methylation and are linked to carcinogenesis and metastasis. Some members of PRMTs have been found to undergo automethylation; however, the biologic significance of this self-modification is not entirely clear. In this report, we demonstrate that R531 of PRMT7 is self-methylated, both in vitro and in vivo Automethylation of PRMT7 plays a key...
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