Article
Regulation of transcription by a protein methyltransferase.
Science (New York, N.Y.) - 25 Jun 1999
Chen D, Ma H, Hong H, Koh S S, Huang S M, Schurter B T, Aswad D W, Stallcup M R
Abstract excerpt
The p160 family of coactivators, SRC-1, GRIP1/TIF2, and p/CIP, mediate transcriptional activation by nuclear hormone receptors. Coactivator-associated arginine methyltransferase 1 (CARM1), a previously unidentified protein that binds to the carboxyl-terminal region of p160 coactivators, enhanced transcriptional activation by nuclear receptors, but only when GRIP1 or SRC-1a was coexpressed. Thus, CARM1 functions...
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