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In vitro generation of human pluripotent stem cell derived lung organoids

23 Mar 2015

Abstract excerpt

Recent breakthroughs in 3-dimensional (3D) organoid cultures for many organ systems have led to new physiologically complex in vitro models to study human development and disease. Here, we report the step-wise differentiation of human pluripotent stem cells (hPSCs) (embryonic and induced) into lung organoids. By manipulating developmental signaling pathways hPSCs generate ventral-anterior foregut spheroids, which...

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PMID: 25803487
DOI: 10.7554/elife.05098

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