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iPSC-derived mesenchymal cells that support alveolar organoid development

19 Sept 2022

Abstract excerpt

Mesenchymal cells are necessary for organ development. In the lung, distal tip fibroblasts contribute to alveolar and airway epithelial cell differentiation and homeostasis. Here, we report a method for generating human induced pluripotent stem cell (iPSC)-derived mesenchymal cells (iMESs) that can induce human iPSC-derived alveolar and airway epithelial lineages in organoids via epithelial-mesenchymal...

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PMID: 36313800
DOI: 10.1016/j.crmeth.2022.100314

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