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Integrating multiplexed imaging and multiscale modeling identifies tumor phenotype conversion as a critical component of therapeutic T cell efficacy.

Cell systems - 17 Apr 2024

Hickey John W, Agmon Eran, Horowitz Nina, Tan Tze-Kai, Lamore Matthew, Sunwoo John B, Covert Markus W, Nolan Garry P

Abstract excerpt

Cancer progression is a complex process involving interactions that unfold across molecular, cellular, and tissue scales. These multiscale interactions have been difficult to measure and to simulate. Here, we integrated CODEX multiplexed tissue imaging with multiscale modeling software to model key action points that influence the outcome of T cell therapies with cancer. The initial phenotype of therapeutic...

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Identifiers

PMID: 38636457
DOI: 10.1016/j.cels.2024.03.004
PMCID: PMC11030795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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