Article
Unveiling spatial complexity in solid tumor immune microenvironments through multiplexed imaging.
Frontiers in immunology - 1 Jan 2024
Scheuermann Sophia, Kristmann Beate, Engelmann Fabienne, Nuernbergk Alice, Scheuermann David, Koloseus Marie, Abed Tayeb, Solass Wiebke, Seitz Christian M
Abstract excerpt
Deciphering cellular components and the spatial interaction network of the tumor immune microenvironment (TIME) of solid tumors is pivotal for understanding biologically relevant cross-talks and, ultimately, advancing therapies. Multiplexed tissue imaging provides a powerful tool to elucidate spatial complexity in a holistic manner. We established and cross-validated a comprehensive immunophenotyping panel...
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