Integrating Multiplexed Imaging and Multiscale Modeling Identifies Tumor Phenotype Transformation as a Critical Component of Therapeutic T Cell Efficacy

Abstract excerpt

<h4>SUMMARY</h4> Cancer progression is a complex process involving interactions that unfold across molecular, cellular, and tissue scales. These multiscale interactions have been difficult to measure and to simulate. Here we integrated CODEX multiplexed tissue imaging with multiscale modeling software, to model key action points that influence the outcome of T cell therapies with cancer. The initial phenotype of...

Topics

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• 3D Printing in Biomedical Research
• CAR-T cell therapy research
• Disease Progression
• Gene Expression Regulation
• Genome
• Neoplasms
• Phenotype
• T-Lymphocytes

Identifiers and source

Literature Corpus work

637d7bf1-a7b9-55fa-9a78-c004939bae0f

DOI

10.1101/2023.12.06.570168