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Article

KLF13 promotes VSMCs phenotypic dedifferentiation by directly binding to the SM22α promoter.

Journal of cellular physiology - 1 May 2024

Yuan Xiaofan, Jiang Chuan, Xue Yuzhou, Guo Fuqiang, Luo Minghao, Guo Lei, Gao Yang, Yuan Tongling, Xu Hui, Chen Hong

Abstract excerpt

Krüppel-like factor 13 (KLF13), a zinc finger transcription factor, is considered as a potential regulator of cardiomyocyte differentiation and proliferation during heart morphogenesis. However, its precise role in the dedifferentiation of vascular smooth muscle cells (VSMCs) during atherosclerosis and neointimal formation after injury remains poorly understood. In this study, we investigated the relationship...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Dedifferentiation

Share to Kruppel-Like Transcription Factors

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

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Share to Plaque, Atherosclerotic

Source

Identifiers

PMID: 38634445
DOI: 10.1002/jcp.31251

Genes

KLF13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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