Article
Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2016
Reddy Marpadga A, Das Sadhan, Zhuo Chen, Jin Wen, Wang Mei, Lanting Linda, Natarajan Rama
Abstract excerpt
OBJECTIVE: Diabetes mellitus accelerates proatherogenic and proinflammatory phenotype of vascular smooth muscle cell (VSMC) associated with vascular complications. Evidence shows that microRNAs (miRNAs) play key roles in VSMC functions, but their role under diabetic conditions is unclear. We profiled miRNAs in VSMC from diabetic mice and examined their role in VSMC dysfunction. APPROACH AND RESULTS: High...
Topics
- Animals
- Aorta, Thoracic
- Aortic Diseases
- Atherosclerosis
- Cell Movement
- Cell Proliferation
- Cells, Cultured
- Computational Biology
- Diabetes Mellitus, Type 2
- Diabetic Angiopathies
- Disease Models, Animal