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CCR2+ monocytes replenish border-associated macrophages in the diseased mouse brain

1 Apr 2024

Abstract excerpt

Border-associated macrophages (BAMs) are tissue-resident macrophages that reside at the border of the central nervous system (CNS). Since BAMs originate from yolk sac progenitors that do not persist after birth, the means by which this population of cells is maintained is not well understood. Using two-photon microscopy and multiple lineage-tracing strategies, we determine that CCR2 + monocytes are significant...

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PMID: 38625796
DOI: 10.1016/j.celrep.2024.114120

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