Back to search

Article

Transgenic Targeting of <i>Fcrls</i> Creates a Highly Efficient Constitutively Active Microglia Cre Line with Differentiated Specificity

2023-09-30

Abstract excerpt

Microglia carry out important functions as the resident macrophages of the brain. To study their role in health and disease, the research community needs tools to genetically modify them with maximum completeness in a manner that distinguishes them from closely related cell-types, such as monocytes. While currently available tamoxifen-inducible CreERT2 lines are able to achieve the differentiation from other cells...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9b768a41-0096-53db-8c20-96c1c4b5bcae
DOI
10.1101/2023.09.30.559914
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Transgenic Targeting of <i>Fcrls</i> Creates a Highly Efficient Constitutively Active Microglia Cre Line with Differentiated SpecificityDOI 10.1101/2023.09.30.559914
A comparative analysis of microglial inducible Cre linesSemantic proximity
Tmem119-EGFP and Tmem119-CreERT2 transgenic mice for labeling and manipulating microgliaSemantic proximity
Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microgliaSemantic proximity
Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microgliaSemantic proximity
Epigenetic Adaptation Drives Monocyte Differentiation into Microglia-Like Cells Upon Engraftment into the Central Nervous SystemSemantic proximity
Fate mapping of peripherally derived macrophages reveals a long-lasting engrafted population that maintains a distinct transcriptomic profile for up to 8 months after Traumatic Brain InjurySemantic proximity
A xeno-free protocol for rapid differentiation of human iPSC-derived microglia from the KOLF2.1J reference lineSemantic proximity
Analyzing microglial phenotypes across neuropathologies: a practical guide.Semantic proximity
STOP floxing around: Specificity and leakiness of inducible Cre/loxP systems.Semantic proximity
An inducible genetic tool for tracking and manipulating specific microglial states in development and diseaseSemantic proximity
A Novel <i>Tmem119-tdTomato</i> Reporter Mouse Model for Studying Microglia in the Central Nervous SystemSemantic proximity
Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutières Syndrome neuropathologySemantic proximity
Select a neighboring publication to make it the new centre.