Article
Differentiation to the CCR2+ inflammatory phenotype in vivo is a constitutive, time-limited property of blood monocytes and is independent of local inflammatory mediators.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2005
Xu Heping, Manivannan Ayyakkannu, Dawson Rosemary, Crane Isabel J, Mack Matthias, Sharp Peter, Liversidge Janet
Abstract excerpt
It is proposed that CCR2+ monocytes are specifically recruited to inflammatory sites, whereas CCR2- monocytes are recruited to normal tissue to become resident macrophages. Whether these subsets represent separate lineages, how differential trafficking is regulated and whether monocytes undergo further differentiation is uncertain. Using a mouse model of autoimmune uveoretinitis we examined monocyte trafficking...
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