Article
Self-renewing resident arterial macrophages arise from embryonic CX3CR1(+) precursors and circulating monocytes immediately after birth.
Nature immunology - 1 Feb 2016
Ensan Sherine, Li Angela, Besla Rickvinder, Degousee Norbert, Cosme Jake, Roufaiel Mark, Shikatani Eric A, El-Maklizi Mahmoud, Williams Jesse W, Robins Lauren, Li Cedric, Lewis Bonnie, Yun Tae Jin, Lee Jun Seong, Wieghofer Peter, Khattar Ramzi, Farrokhi Kaveh, Byrne John, Ouzounian Maral, Zavitz Caleb C J, Levy Gary A, Bauer Carla M T, Libby Peter, Husain Mansoor, Swirski Filip K, Cheong Cheolho, Prinz Marco, Hilgendorf Ingo, Randolph Gwendalyn J, Epelman Slava, Gramolini Anthony O, Cybulsky Myron I, Rubin Barry B, Robbins Clinton S
Abstract excerpt
Resident macrophages densely populate the normal arterial wall, yet their origins and the mechanisms that sustain them are poorly understood. Here we use gene-expression profiling to show that arterial macrophages constitute a distinct population among macrophages. Using multiple fate-mapping approaches, we show that arterial macrophages arise embryonically from CX3CR1(+) precursors and postnatally from bone...
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