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Article

iPSC-based modeling of preeclampsia identifies epigenetic defects in extravillous trophoblast differentiation

25 Mar 2024

Abstract excerpt

. We previously derived induced pluripotent stem cells (iPSCs) from placentas of PE patients and characterized abnormalities in formation of syncytiotrophoblast and responses to changes in oxygen tension. In this study, we converted these primed iPSC to naïve iPSC, and then derived trophoblast stem cells (TSCs) and EVT to evaluate molecular mechanisms underlying PE. We found that primed (but not naïve)...

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PMID: 38623329
DOI: 10.1016/j.isci.2024.109569

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