Article

BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia

2025-12-01

Abstract excerpt

Preeclampsia, a life threatening hypertensive disorder of pregnancy, is a leading cause of maternal and perinatal morbidity and mortality. Its early onset form (EO PE), requiring delivery before 34 weeks of gestation, is particularly severe and closely linked to defective trophoblast differentiation. Here, we identify BRCA1-associated protein 1 (BAP1) and its cofactors ASXL2 and ASXL3 are upregulated in EO PE plac...

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Literature Corpus work: 55ee8dab-4e2a-5208-97fc-6fc075ffcf94
DOI: 10.1101/2025.11.28.691117

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