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Article

Modeling preeclampsia using human induced pluripotent stem cells.

Scientific reports - 15 Mar 2021

Horii Mariko, Morey Robert, Bui Tony, Touma Ojeni, Nelson Katharine K, Cho Hee-Young, Rishik Hannah, Laurent Louise C, Parast Mana M

Abstract excerpt

Preeclampsia (PE) is a pregnancy-specific hypertensive disorder, affecting up to 10% of pregnancies worldwide. The primary etiology is considered to be abnormal development and function of placental cells called trophoblasts. We previously developed a two-step protocol for differentiation of human pluripotent stem cells, first into cytotrophoblast (CTB) progenitor-like cells, and then into both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33723311
DOI: 10.1038/s41598-021-85230-5
PMCID: PMC7961010

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