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Article

Human Trophoblast Differentiation Is Associated With Profound Gene Regulatory and Epigenetic Changes

11 Jul 2019

Abstract excerpt

Defective placental implantation and vascularization with accompanying hypoxia contribute to preeclampsia (PE), a leading cause of maternal and neonatal morbidity and mortality. Genetic and epigenetic mechanisms underlying differentiation of proliferative cytotrophoblasts (CytTs) to multinucleated syncytiotrophoblast (SynT) are incompletely defined. The SynT performs key functions in nutrient and gas exchange,...

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PMID: 31294776
DOI: 10.1210/en.2019-00144

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