Article
Enhanced ROS Production in Mitochondria from Prematurely Aging mtDNA Mutator Mice.
Biochemistry. Biokhimiia - 1 Feb 2024
Shabalina Irina G, Edgar Daniel, Gibanova Natalia, Kalinovich Anastasia V, Petrovic Natasa, Vyssokikh Mikhail Yu, Cannon Barbara, Nedergaard Jan
Abstract excerpt
An increase in mitochondrial DNA (mtDNA) mutations and an ensuing increase in mitochondrial reactive oxygen species (ROS) production have been suggested to be a cause of the aging process ("the mitochondrial hypothesis of aging"). In agreement with this, mtDNA-mutator mice accumulate a large amount of mtDNA mutations, giving rise to defective mitochondria and an accelerated aging phenotype. However,...
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