Article
Characterization of mitochondrial function in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function.
Journal of bioenergetics and biomembranes - 1 Jun 2016
Atlante Anna, Favia Maria, Bobba Antonella, Guerra Lorenzo, Casavola Valeria, Reshkin Stephan Joel
Abstract excerpt
Evidence supporting the occurrence of oxidative stress in Cystic Fibrosis (CF) is well established and the literature suggests that oxidative stress is inseparably linked to mitochondrial dysfunction. Here, we have characterized mitochondrial function, in particular as it regards the steps of oxidative phosphorylation and ROS production, in airway cells either homozygous for the F508del-CFTR allele or stably...
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