Article
Enhanced ROS production and antioxidant defenses in cybrids harbouring mutations in mtDNA.
Neuroscience letters - 2 Jan 2006
Vives-Bauza Cristofol, Gonzalo Ricardo, Manfredi Giovanni, Garcia-Arumi Elena, Andreu Antonio L
Abstract excerpt
It has been suggested that mutations in mitochondrial DNA (mtDNA) can produce an increase in reactive oxygen species (ROS) and that this can play a major role in the pathogenic mechanisms of mitochondrial encephalomyopathies. Many studies exist using electron transport chain (ETC) inhibitors, how...
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