Article
In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice.
Aging cell - 1 Aug 2014
Logan Angela, Shabalina Irina G, Prime Tracy A, Rogatti Sebastian, Kalinovich Anastasia V, Hartley Richard C, Budd Ralph C, Cannon Barbara, Murphy Michael P
Abstract excerpt
In mtDNA mutator mice, mtDNA mutations accumulate leading to a rapidly aging phenotype. However, there is little evidence of oxidative damage to tissues, and when analyzed ex vivo, no change in production of the reactive oxygen species (ROS) superoxide and hydrogen peroxide by mitochondria has been reported, undermining the mitochondrial oxidative damage theory of aging. Paradoxically, interventions that decrease...
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