Article
Comparative bioenergetic study of neuronal and muscle mitochondria during aging.
Free radical biology & medicine - 1 Oct 2013
Li Hongzhi, Kumar Sharma Lokendra, Li Youfen, Hu Peiqing, Idowu Abimbola, Liu Danhui, Lu Jianxin, Bai Yidong
Abstract excerpt
Mitochondrial respiratory chain defects have been associated with various diseases and with normal aging, particularly in tissues with high energy demands, including brain and skeletal muscle. Tissue-specific manifestation of mitochondrial DNA (mtDNA) mutations and mitochondrial dysfunction are hallmarks of mitochondrial diseases although the underlying mechanisms are largely unclear. Previously, we and others...
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