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Article

Bioenergetic consequences of compromised mitochondrial DNA repair in the mouse heart.

Biochemical and biophysical research communications - 12 Oct 2018

McLaughlin Kelsey L, McClung Joseph M, Fisher-Wellman Kelsey H

Abstract excerpt

The progeroid phenotype of mitochondrial DNA (mtDNA) mutator mice has been nebulously attributed to general mitochondrial 'dysfunction', though few studies have rigorously defined the bioenergetic consequences of accumulating mtDNA mutations. Comprehensive mitochondrial diagnostics was employed to interrogate the bioenergetic properties of isolated cardiac mitochondria from mtDNA mutator mice and wild type...

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Identifiers

PMID: 30217445
DOI: 10.1016/j.bbrc.2018.09.022
PMCID: PMC6173612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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