Article
New insights into the bioenergetics of mitochondrial disorders using intracellular ATP reporters.
Molecular biology of the cell - 1 Sept 2003
Gajewski Carl D, Yang Lichuan, Schon Eric A, Manfredi Giovanni
Abstract excerpt
Mutations in mitochondrial DNA (mtDNA) cause impairment of ATP synthesis. It was hypothesized that high-energy compounds, such as ATP, are compartmentalized within cells and that different cell functions are sustained by different pools of ATP, some deriving from mitochondrial oxidative phosphorylation (OXPHOS) and others from glycolysis. Therefore, an OXPHOS dysfunction may affect different cell compartments to...
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