Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling.

Cell reports. Medicine - 21 May 2024

He Baoyu, Bie Qingli, Zhao Rou, Yan Yugang, Dong Guanjun, Zhang Baogui, Wang Sen, Xu Wenrong, Tian Dongxing, Hao Yujun, Zhang Yanhua, Zhao Mingsheng, Xiong Huabao, Zhang Bin

Abstract excerpt

Key gene mutations are essential for colorectal cancer (CRC) development; however, how the mutated tumor cells impact the surrounding normal cells to promote tumor progression has not been well defined. Here, we report that PIK3CA mutant tumor cells transmit oncogenic signals and result in malignant transformation of intestinal epithelial cells (IECs) via paracrine exosomal arachidonic acid (AA)-induced H3K4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arachidonic Acid
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Assembly and Disassembly

Share to Class I Phosphatidylinositol 3-Kinases

Share to Exosomes

Share to Histones

Share to Intestinal Mucosa

Source

Open in PubMed Open full text

Identifiers

PMID: 38614093
DOI: 10.1016/j.xcrm.2024.101510
PMCID: PMC11148513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling.PMID 38614093Read ↗

Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancerSemantic proximity Read ↗

“A Fine-Tuned Phosphatidylinositol Profile Contributes to Colonocyte Differentiation and Malignization: Evidence From Integrated Omics”Semantic proximity Read ↗

Targeting Mevalonate Pathway Enhances the efficacy of 5-Fluorouracil by regulating pyroptosisSemantic proximity Read ↗

Phytic Acid (InsP <sub>6</sub> ) Activates HDAC3 Epigenetic Axis to Maintain Intestinal Barrier FunctionSemantic proximity Read ↗

Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA-Mutant Colorectal Cancer.Semantic proximity Read ↗

m6A demethylase ALKBH5 suppresses proliferation and migration of enteric neural crest cells by regulating TAGLN in Hirschsprung's diseaseSemantic proximity Read ↗

G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1Semantic proximity Read ↗

Short chain fatty acids regulate the chromatin landscape and distinct gene expression changes in human colorectal cancer cellsSemantic proximity Read ↗

NAA40 contributes to colorectal cancer growth by controlling PRMT5 expressionSemantic proximity Read ↗

Aspirin sensitivity of PIK3CA-mutated Colorectal Cancer: potential mechanisms revisited.Semantic proximity Read ↗

ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2Semantic proximity Read ↗

The m6A methyltransferase METTL3 modifies Kcnk6 promoting on inflammation associated carcinogenesis is essential for colon homeostasis and defense system through histone lactylation dependent YTHDF2 bindingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.