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Article

G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1

1 Jan 2018

Abstract excerpt

Rationale: G9a is genetically deregulated in various tumor types and is important for cell proliferation; however, the mechanism underlying G9a-induced carcinogenesis, especially in colorectal cancer (CRC), is unclear. Here, we investigated if G9a exerts oncogenic effects in CRC by increasing polo-like kinase 1 (Plk1) expression. Thus, we further characterized the detailed molecular mechanisms. Methods: The role...

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PMID: 29774081
DOI: 10.7150/thno.23824

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