“A Fine-Tuned Phosphatidylinositol Profile Contributes to Colonocyte Differentiation and Malignization: Evidence From Integrated Omics”

Abstract excerpt

<h4>ABSTRACT</h4> Membrane lipid composition changes concomitantly with human colonocyte differentiation, a tightly regulated process occurring along the colon crypt. This process is heavily disrupted in colon cancer. Nonetheless, the regulatory mechanisms driving these changes, especially the replacement of arachidonic acid phosphatidylinositol species with monounsaturated fatty acid species, and how they are al...

Topics

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• Cancer, Lipids, and Metabolism
• Comorbidity
• Diet, Healthy
• Evidence-Based Medicine
• Healthy Lifestyle
• Liver Disease Diagnosis and Treatment
• Metabolomics and Mass Spectrometry Studies
• Sphingolipid Metabolism and Signaling

Identifiers and source

Literature Corpus work

e90ed0a5-e223-5bc2-bfe1-eff70c05466b

DOI

10.64898/2026.02.20.706976