Article

Phytic Acid (InsP <sub>6</sub> ) Activates HDAC3 Epigenetic Axis to Maintain Intestinal Barrier Function

2024-09-16

Abstract excerpt

While HDAC inhibition shows promise in cancer treatment, pan-HDAC inhibitors cause gastrointestinal issues in 48% of patients. Understanding HDAC activation mechanisms is crucial to treat diverse diseases beyond cancer. Our study reveals the essential role of inositol polyphosphate multikinase (IPMK) and inositol hexakisphosphate (InsP 6 or phytic acid), enriched in vegan diets, in activating the HDAC3 epigenetic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f57cf65-c285-5529-8680-defe9ad01916
DOI: 10.1101/2024.09.15.613154

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Phytic Acid (InsP <sub>6</sub> ) Activates HDAC3 Epigenetic Axis to Maintain Intestinal Barrier FunctionDOI 10.1101/2024.09.15.613154Read

Histone Deacetylases in the Inflamed Intestinal Epithelium—Promises of New Therapeutic StrategiesSemantic proximity Read

IPMK regulates HDAC3 activity and histone H4 acetylation in human cellsSemantic proximity Read

Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling.Semantic proximity Read

The role of HDAC3 in inflammation: mechanisms and therapeutic implicationsSemantic proximity Read

HDAC6-Mediated FoxO1 Acetylation And Phosphorylation Control Periodontal Inflammatory ResponsesSemantic proximity Read

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase is a distant IPK member with a singular inositide binding site for axial 2-OH recognition.Semantic proximity Read

Arginine Di-methylation of RIPK3 Safeguards Necroptosis for Intestinal HomeostasisSemantic proximity Read

PTGER4 signaling regulates class IIa HDAC function and SPINK4 mRNA levels in rectal epithelial cellsSemantic proximity Read

The m6A methyltransferase METTL3 modifies Kcnk6 promoting on inflammation associated carcinogenesis is essential for colon homeostasis and defense system through histone lactylation dependent YTHDF2 bindingSemantic proximity Read

Anti-cancer function of phytic acidSemantic proximity Read

IPMK: A versatile regulator of nuclear signaling events.Semantic proximity Read

Targeting Histone Deacetylase-3 Blocked Epithelial-Mesenchymal Plasticity And Metastatic Dissemination In Gastric CancerSemantic proximity Read