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Article

Aspirin sensitivity of PIK3CA-mutated Colorectal Cancer: potential mechanisms revisited.

Cellular and molecular life sciences : CMLS - 2 Jul 2022

Hall Daniella C N, Benndorf Ralf A

Abstract excerpt

PIK3CA mutations are amongst the most prevalent somatic mutations in cancer and are associated with resistance to first-line treatment along with low survival rates in a variety of malignancies. There is evidence that patients carrying PIK3CA mutations may benefit from treatment with acetylsalicylic acid, commonly known as aspirin, particularly in the setting of colorectal cancer. In this regard, it has been...

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Source

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Identifiers

PMID: 35780223
DOI: 10.1007/s00018-022-04430-y
PMCID: PMC9250486

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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