Article

Targeting Mevalonate Pathway Enhances the efficacy of 5-Fluorouracil by regulating pyroptosis

2024-11-05

Abstract excerpt

<title>Abstract</title> <p>The 5-fluorouracil (5-FU)-based chemotherapy regimen is a primary strategy for treating pancreatic cancer (PC).However, challenges related to 5-FU resistance persist. Investigating the mechanisms of 5-FU resistance and identifying a clinically viable therapeutic strategy are crucial for improving the prognosis of PC. Here, through clinical samples analysis, we found that the expression...

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Literature Corpus work: 21e89118-265b-57bd-89eb-f09ae4731ae3
DOI: 10.21203/rs.3.rs-5024083/v2

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