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Article

Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in PIK3CA-Mutant Colorectal Cancer.

Molecular cancer research : MCR - 1 Feb 2020

Miller Samuel A, Policastro Robert A, Savant Sudha S, Sriramkumar Shruthi, Ding Ning, Lu Xiaoyu, Mohammad Helai P, Cao Sha, Kalin Jay H, Cole Philip A, Zentner Gabriel E, O'Hagan Heather M

Abstract excerpt

Activation of the epithelial-to-mesenchymal transition (EMT) program is a critical mechanism for initiating cancer progression and migration. Colorectal cancers contain many genetic and epigenetic alterations that can contribute to EMT. Mutations activating the PI3K/AKT signaling pathway are observed in >40% of patients with colorectal cancer contributing to increased invasion and metastasis. Little is known...

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Identifiers

PMID: 31704733
DOI: 10.1158/1541-7786.MCR-19-0748
PMCID: PMC7002231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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