Article
Phenotypic Heterogeneity of Cancer Associated Fibroblasts in Cervical Cancer Progression: FAP as a Central Activation Marker.
Cells - 22 Mar 2024
Bueno-Urquiza Lesly Jazmin, Godínez-Rubí Marisol, Villegas-Pineda Julio César, Vega-Magaña Alejandra Natali, Jave-Suárez Luis Felipe, Puebla-Mora Ana Graciela, Aguirre-Sandoval Gloria Estefanía, Martínez-Silva María Guadalupe, Ramírez-de-Arellano Adrián, Pereira-Suárez Ana Laura
Abstract excerpt
Cervical cancer (CC) is the fourth leading cancer among women and is one of the principal gynecological malignancies. In the tumor microenvironment, cancer-associated fibroblasts (CAFs) play a crucial role during malignant progression, exhibiting a variety of heterogeneous phenotypes. CAFs express phenotypic markers like fibroblast activation protein (FAP), vimentin, S100A4, α-smooth muscle actin (αSMA), and...
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