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Article

Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts.

Matrix biology : journal of the International Society for Matrix Biology - 1 Apr 2018

Avery Diana, Govindaraju Priya, Jacob Michele, Todd Leslie, Monslow James, Puré Ellen

Abstract excerpt

Activated fibroblasts are key players in the injury response, tumorigenesis, fibrosis, and inflammation. Dichotomous outcomes in response to varied stroma-targeted therapies in cancer emphasize the need to disentangle the roles of heterogeneous fibroblast subsets in physiological and pathophysiological settings. In wound healing, fibrosis, and myriad tumor types, fibroblast activation protein (FAP) and...

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Identifiers

PMID: 29248556
DOI: 10.1016/j.matbio.2017.12.003
PMCID: PMC5910258

Genes

FAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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