Family study designs in the age of genome-wide association studies: experience from the Framingham Heart Study.

Abstract excerpt

PURPOSE OF REVIEW: The past year has seen the publication of many genome-wide association studies, most of which are case-control studies. These publications are at the forefront of current research into the examination of genetic effects for numerous diseases, including diabetes, heart disease and cancer. Over the past 25 years the tour de force of genetics research has been in family studies, using segregation,...

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