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Molecular phenotyping of small cell lung cancer using targeted cfDNA profiling of transcriptional regulatory regions

10 Apr 2024

Abstract excerpt

We report an approach for cancer phenotyping based on targeted sequencing of cell-free DNA (cfDNA) for small cell lung cancer (SCLC). In SCLC, differential activation of transcription factors (TFs), such as ASCL1, NEUROD1, POU2F3, and REST defines molecular subtypes. We designed a targeted capture panel that identifies chromatin organization signatures at 1535 TF binding sites and 13,240 gene transcription start...

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PMID: 38598634
DOI: 10.1126/sciadv.adk2082

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