Detecting Small Cell Transformation in Patients with Advanced EGFR Mutant Lung Adenocarcinoma through Epigenomic cfDNA Profiling.

doi:10.1158/1078-0432.CCR-24-0466

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Detecting Small Cell Transformation in Patients with Advanced EGFR Mutant Lung Adenocarcinoma through Epigenomic cfDNA Profiling.

Clinical cancer research : an official journal of the American Association for Cancer Research - 3 Sept 2024

El Zarif Talal, Meador Catherine B, Qiu Xintao, Seo Ji-Heui, Davidsohn Matthew P, Savignano Hunter, Lakshminarayanan Gitanjali, McClure Heather M, Canniff John, Fortunato Brad, Li Rong, Banwait Mandeep K, Semaan Karl, Eid Marc, Long Henry, Hung Yin P, Mahadevan Navin R, Barbie David A, Oser Matthew G, Piotrowska Zofia, Choueiri Toni K, Baca Sylvan C, Hata Aaron N, Freedman Matthew L, Berchuck Jacob E

Abstract excerpt

PURPOSE: Histologic transformation to small cell lung cancer (SCLC) is a mechanism of treatment resistance in patients with advanced oncogene-driven lung adenocarcinoma (LUAD) that currently requires histologic review for diagnosis. Herein, we sought to develop an epigenomic cell-free DNA (cfDNA)-based approach to noninvasively detect small cell transformation in patients with EGFR mutant (EGFRm) LUAD....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell-Free Nucleic Acids

Share to Cell Transformation, Neoplastic

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Epigenomics

Share to ErbB Receptors

Share to Small Cell Lung Carcinoma

Source

Open in PubMed Open full text

Identifiers

PMID: 38912901
DOI: 10.1158/1078-0432.CCR-24-0466
PMCID: PMC11369616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detecting Small Cell Transformation in Patients with Advanced EGFR Mutant Lung Adenocarcinoma through Epigenomic cfDNA Profiling.PMID 38912901Read ↗

Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformationSemantic proximity Read ↗

Molecular phenotyping of small cell lung cancer using targeted cfDNA profiling of transcriptional regulatory regionsSemantic proximity Read ↗

Cell-free Tumor Methylome Analysis of Small Cell Lung Cancer Patients Identifies Subgroups with Prognostic AssociationsSemantic proximity Read ↗

Spatial multi-omics unveils the monoclonal origin, neuroendocrine plasticity, and microenvironment niches in combined small cell lung cancerSemantic proximity Read ↗

Genomic alterations and transcriptional phenotypes in circulating free DNA and matched metastatic tumor.Semantic proximity Read ↗

Genome-wide profiling of non-smoking-related lung cancer cells reveals common RB1 rearrangements associated with histopathologic transformation in EGFR-mutant tumors.Semantic proximity Read ↗

Whole Exome Sequencing Study Identifies Distinct Characteristics of Transformed Small Cell Lung Cancer With EGFR Mutation Compared to De Novo Small Cell and Primary Non‐Small Cell Lung CancersSemantic proximity Read ↗

Transcriptomic analysis of transformed small-cell lung cancer from EGFR-mutated lung adenocarcinoma reveals distinct subgroups and precision therapy opportunitiesSemantic proximity Read ↗

Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypesSemantic proximity Read ↗

Genomic alterations and transcriptional phenotypes in circulating tumor DNA and matched metastatic tumorSemantic proximity Read ↗

Comprehensive multimodal and multiomic profiling reveals epigenetic and transcriptional reprogramming in lung tumorsSemantic proximity Read ↗

Cell-free DNA methylation-defined prognostic subgroups in small-cell lung cancer identified by leukocyte methylation subtractionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.